Dermatology · High-Risk Medication

Isotretinoin Cumulative
Dose Calculator

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Isotretinoin (Accutane) — Cumulative Dose Calculator

High-risk medication · Last reviewed: March 2026

ISOTRETINOIN IS A POTENT TERATOGEN (Category X). It must never be used during pregnancy. Any pregnancy occurring during or shortly after treatment carries an extremely high risk of severe fetal abnormalities.

Females of childbearing potential must be enrolled in the appropriate Pregnancy Prevention Programme (iPLEDGE in the USA; local PPP in the UK/EU/Australia) before starting treatment and must comply with all contraception requirements.

This calculator is for educational reference only. All dosing decisions must be made by the treating dermatologist in compliance with local regulations.

I understand isotretinoin is a teratogen, that pregnancy prevention programme compliance is mandatory for female patients, and this tool is educational only.